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Asia University College of Medical and Health Science

Welcome to College of Health Science
English

Asia University 168

 

Introduction of Dean

 

 T-portfolio

Shin-Da Lee Ph.D.                                 

Distinguished Professor

Dean, College of Medical and Health Sciences, Asia University

Vice President, Taiwan Development Institute, Taiwan   

2010 Top Ten Outstanding Young Person Award in Taiwan 

Tel:886-4-23323456 Ext.5100

Mobile: +886-928979005

Fax: +886-4-23321215

E-mail address:l:leeshinda@gmail.com

Address: 500, Lioufeng Rd., Wufeng, Taichung 41354, Taiwan

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Education:

2001 Ph.D., Department of Physical Therapy & Exercise Science, State University of New York at Buffalo, USA

1999 M.S., Department of Physical Therapy & Exercise Science, State University of New York at Buffalo, USA 

1993 B.S. in Physical Therapy, Department of Rehabilitation Medicine, Kaohsiung Medical College, Taiwan

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Working Experience:

2016-current  Dean, College of Medical and Health Sciences, Asia University

2008-current  Professor, China Medical University, Taiwan

2013-current  Professor, Department of Physical Therapy and Graduate Institute of Rehabilitation Science (MS Program), China Medical University, Taiwan

2013-current  Professor, Graduate Institute of Clinical Medicine (PhD program), China Medical University, Taiwan

2013-current  Adjunct Professor, Department of Healthcare Administration, Asia University, Taichung, Taiwan

2014-2015    Professor and Dean for International and Public Affairs, China Medical University

2012-current  Vice President, Taiwan Development Institute

2010-current  President, Society of Adaptive Science in Taiwan

2011-2013    Professor and Dean of International Affair, China Medical University

2008-2011    Departmental Chair, Department of Physical Therapy, Graduate Institute of Rehabilitation Science, China Medical University, Taiwan

2006-2008    Associate Professor, Department Chair, Department of Physical Therapy, China Medical University, Taiwan

2005-2006    Associate Professor, School of Physical Therapy, Chung Shan Medical University

2001-2005    Assistant professor, School of Physical Therapy, Chung Shan Medical University

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Honors

2015 Taiwan Excellence Gold

2013 Research Excellence Award, National Scientific Council, Taiwan

2013 International Plato Award for Education Achievement

2013 IBC Top 100 Educators-2013

2010 Honorary Citizen, Taichung City

2011 Outstanding Research Award, China Medical University, Taiwan

2010 Top Ten Outstanding Young Persons Award, Taiwan

2009 Outstanding Research Award, China Medical University, Taiwan

2008 Outstanding Research Award, China Medical University, Taiwan

2008 Ta-You Wu Memorial Award, National Science Council, Taiwan

2007 Outstanding Research Award, China Medical University, Taiwan

2006 Outstanding Research Award, China Medical University, Taiwan

2000 ATS Travel Grand Award, American Thoracic Society

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Editorial Board Members:

Editorial Board Members, Physical Medicine and Rehabilitation – International

Editorial Board Members, Journal of diabetes and obesity

Editorial Board Members, Chinese Journal of Physiology

Editorial Board Members, Journal of Physical Therapy

Editorial Board Members, Adaptive Medicine

Editorial Board Members, Journal of Physical Education in higher Education

 

Invited Reviewer (Frequently):

Invited Reviewer, American Journal of Physiology.

Invited Reviewer, Journal of Applied Physiology

Invited Reviewer, Journal of Molecular and Cellular Cardiology

Invited Reviewer, International Journal of Cardiology

Invited Reviewer, Journal of Molecular and Cellular Cardiology 

Invited Reviewer, International Journal of Behavioral Nutrition and Physical Activity 

Invited Reviewer, British Journal of Pharmacology

Invited Reviewer, Clinica Chimica Acta

Invited Reviewer, Journal of diabetes and metabolism

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Membership of Professional Societies

Congress Chairman, 12th Asian Confederation for Physical Therapy (ACPT)

2013 Congress Chairman, International Congress, Asia Western Pacific Region (AWP) of World Confederation for Physical Therapy (WCPT)

Board Member of Executive Committee and Secretary 2011-2013, Asia Western Pacific Region (AWP) of World Confederation for Physical Therapy (WCPT)

Member, American Physiology Society

Member, American College of Sports Medicine

Member, American Academy of Sleep Medicine

Premium Member, American Heart Society

Member, The Society for the study of androgen deficiency

Lifetime Member, Chinese Physiological Society

Member, Taiwan Medical Association for the Study of Obesity

Member, Physical Therapist Taiwan

Board Member of Executive Committee, Physical Therapy Association of ROC

Board Member of Supervisors, Taiwan Health Movement Alliance

Executive Consultants, Taiwan Sport Technology Association

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Patents: 

CN102727363

US2012253242

TW201238583

JP2012213616

DE102012005024

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Books:

1. Lee, Shin-Da. The neuromodulation of ventilation in obese Zucker rats. Bell & Howell information and Learing Company. 2001, 245 pages. ISBN 0-493-20790-2.

2. Shin-Da Lee. Endogenous opioids modulate ventilation and peak oxygen consumption in obese Zucker rats. Thesis (M.S.)--State University of New York at Buffalo, 1999. 

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Published Journal Paper:

Highlight Papers in Obesity and Stroke

1. (First Author) Lee SD. Nakano H. Gosselin LE. Krasney JA. Schlenker EH. Farkas GA. Endogenous opioids modulate ventilation and peak oxygen consumption in obese Zucker rats. American Journal of Respiratory & Critical Care Medicine. 162(3 Pt 1):1009-15, 2000.Sep. Impact Factor : 11.986

2. (First Author) Lee SD. Nakano H. Farkas GA. NMDA receptor-mediated modulation of ventilation in obese Zucker rats. International Journal of Obesity & Related Metabolic Disorders. 25(7):997-1004, 2001 Jul. Imapct Factor: 5.386

3. (Correspondence Author) Lin TB, Lo MJ, Huang CY, Ting H, Lee SD*. GABAergic modulation of ventilatory response to acute and sustained hypoxia in obese Zucker rats. International Journal of Obesity 29(2):188-195, 2005 Feb. Imapct Factor: 5.386

4. (First Author) Lee SD, Kuo WW, Wu CH, Lin YM, Lin JA, Lu MC, Yang AL, Liu JY, Wang SG, Liu CJ, Chen LM, Huang CY. Effects of short- and long-Term hypobaric hypoxia on Bcl2 family in rat heart. International Journal of Cardiology  108(3):376-84, 2006 Apr. Impact Factor: 6.175

5. Yang AL, Chao JI, Lee SD*. Altered insulin-mediated and insulin-like growth factor-1-mediated vasorelaxation in aortas of obese Zucker rats. International Journal of Obesity. 31(1):72-7, 2007 Jan. Imapct Factor: 5.386

6. (First Author) Lee SD, Kuo WW, Lin JA, Chu YF, Wang CK, Yeh YL, Wang SG, Liu JY, Chang MH, Huang CY. Effects of long-term intermittent hypoxia on mitochondrial and Fas death receptor dependent apoptotic pathways in rat hearts. International Journal of Cardiology. 116(3):348-56, 2007 Apr. Imapct Factor: 6.175

7. (First Author) Lee SD, Tzang BS, Kuo WW, Lin YM, Yang AL, Chen SH, Tsai FJ, Wu FL, Lu MJ, Huang CY. Cardiac Fas receptor-dependent apoptotic pathway in obese Zucker rats. Obesity (Silver Spring). 15(10):2407-15, 2007 Oct. Impact Factor, 4.389

8. (Correspondence Author) Lu MC, Tzang BS, Kuo WW, Wu FL, Chen YS, Tsai CH, Huang CY, Lee SD*. More activated cardiac mitochondrial dependent apoptotic pathway in obese Zucker rat. Obesity (Silver Spring). 15(11):2634-42, 2007 Nov. Impact Factor, 4.389

9. (Correspondence Author) Wu MK, Huang CY, Liou YJ, Wang CK, Lee SD*. Glucose-insulin homeostasis, lipid profiles and GH-IGF-IGFBP axis in clozapine-treated schizophrenic obesity versus non-psychiatric obesity. International Journal of Obesity. 32(3):436-42, 2008 Mar. Imapct Factor: 5.386

10. (Correspondence Author)   Cheng SM, Ho TJ, Yang AL, Chen IJ, Kao CL, Wu FN, Lin JA, Kuo CH, Ou HC, Huang CY, Lee SD. Exercise training enhances cardiac IGFI-R/PI3K/Akt and Bcl-2 family associated pro-survival pathways in streptozotocin-induced diabetic rats.  Int J Cardiol. 2013 Jul 31;167(2):478-85. Impact Factor: 6.175

11. (First Author)  Lee SD, Lai TW, Lin SZ, Lin CH, Hsu YH, Li CY, Wang HJ, Lee W, Su CY, Yu YL, Shyu WC. Role of stress-inducible protein-1 in recruitment of bone marrow derived cells into the ischemic brains.  EMBO Mol Med. 2013 Aug;5(8):1227-46.  Impact Factor: 8.245

12. (Correspondence Author)  Lai MC, Lin JG, Pai PY, Lai MH, Lin YM, Yeh YL, Cheng SM, Liu YF, Huang CY, Lee SD*. Protective effect of salidroside on cardiac apoptosis in mice with chronic intermittent hypoxia. Int J Cardiol. 2014 Jul 1;174(3):565-73. Impact Factor: 6.175

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Published Journal Paper:

  1. (First Author) Lee SD, Nakano H, Gosselin LE, Krasney JA, Schlenker EH, Farkas GA. Endogenous opioids modulate ventilation and peak oxygen consumption in obese Zucker rats. Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 1):1009-15. doi: 10.1164/ajrccm.162.3.9909058. PMID: 10988122.
  2. (First Author) Lee SD, Nakano H, Farkas GA. GABAergic modulation of ventilation and peak oxygen consumption in obese Zucker rats. J Appl Physiol (1985). 2001 May;90(5):1707-13. doi: 10.1152/jappl.2001.90.5.1707. PMID: 11299259.
  3. Nakano H, Magalang UJ, Lee SD, Krasney JA, Farkas GA. Serotonergic modulation of ventilation and upper airway stability in obese Zucker rats. Am J Respir Crit Care Med. 2001 Apr;163(5):1191-7. doi: 10.1164/ajrccm.163.5.2004230. PMID: 11316658.
  4. (First Author) Lee SD, Nakano H, Farkas GA. NMDA receptor-mediated modulation of ventilation in obese Zucker rats. Int J Obes Relat Metab Disord. 2001 Jul;25(7):997-1004. doi: 10.1038/sj.ijo.0801663. PMID: 11443498.
  5. (First Author) Lee SD, Magalang UJ, Krasney JA, Farkas GA. Opioidergic modulation of ventilatory response to sustained hypoxia in obese Zucker rats. Obes Res. 2001 Jul;9(7):407-13. doi: 10.1038/oby.2001.53. PMID: 11445663.
  6. Nakano H, Lee SD, Ray AD, Krasney JA, Farkas GA. Role of nitric oxide in thermoregulation and hypoxic ventilatory response in obese Zucker rats. Am J Respir Crit Care Med. 2001 Aug 1;164(3):437-42. doi: 10.1164/ajrccm.164.3.2010142. PMID: 11500346.
  7. Nakano H, Lee SD, Farkas GA. Dopaminergic modulation of ventilation in obese Zucker rats. J Appl Physiol (1985). 2002 Jan;92(1):25-32. doi: 10.1152/jappl.2002.92.1.25. PMID: 11744639.
  8. Ray AD, Roberts AJ, Lee SD, Farkas GA, Michlin C, Rifkin DI, Ostrow PT, Krasney JA. Exercise delays the hypoxic thermal response in rats. J Appl Physiol (1985). 2003 Jul;95(1):272-8. doi: 10.1152/japplphysiol.00057.2003. Epub 2003 Mar 7. PMID: 12626482.
  9. (Correspondence Author) Lin TB, Lo MJ, Huang CY, Ting H, Lee SD*. GABAergic modulation of ventilatory response to acute and sustained hypoxia in obese Zucker rats. Int J Obes (Lond). 2005 Feb;29(2):188-95. doi: 10.1038/sj.ijo.0802828. PMID: 15505631.
  10. (First Author) Lee SD, Nakano H, Farkas GA. Adenosinergic modulation of ventilation in obese zucker rats. Obes Res. 2005 Mar;13(3):545-55. doi: 10.1038/oby.2005.58. PMID: 15833940.
  11. Kuo WW, Chu CY, Wu CH, Lin JA, Liu JY, Hsieh YH, Ueng KC, Lee SD, Hsieh DJ, Hsu HH, Chen LM, Huang CY. Impaired IGF-I signalling of hypertrophic hearts in the developmental phase of hypertension in genetically hypertensive rats. Cell Biochem Funct. 2005 Sep-Oct;23(5):325-31. doi: 10.1002/cbf.1244. PMID: 15996002.
  12. (First Author) Lee SD, Kuo WW, Wu CH, Lin YM, Lin JA, Lu MC, Yang AL, Liu JY, Wang SG, Liu CJ, Chen LM, Huang CY. Effects of short- and long-term hypobaric hypoxia on Bcl2 family in rat heart. Int J Cardiol. 2006 Apr 14;108(3):376-84. doi: 10.1016/j.ijcard.2005.05.046. Epub 2005 Jul 11. PMID: 16005992.
  13. Ting H, Lee SD, Chung AH, Chuang ML, Chen GD, Liao JM, Chang CL, Chiou TS, Lin TB. Effects of bilateral T2-sympathectomy on static and dynamic heart rate responses to exercise in hyperhidrosis patients. Auton Neurosci. 2005 Aug 31;121(1-2):74-80. doi: 10.1016/j.autneu.2005.05.007. PMID: 16055388.
  14. Kuo WW, Chu CY, Wu CH, Lin JA, Liu JY, Ying TH, Lee SD, Hsieh YH, Chu CH, Lin DY, Hsu HH, Huang CY. The profile of cardiac cytochrome c oxidase (COX) expression in an accelerated cardiac-hypertrophy model. J Biomed Sci. 2005;12(4):601-10. doi: 10.1007/s11373-005-7373-2. Epub 2005 Nov 10. PMID: 16132109.
  15. Wu CH, Liu JY, Wu JP, Hsieh YH, Liu CJ, Hwang JM, Lee SD, Chen LM, Chang MH, Kuo WW, Shyu JC, Tsai JH, Huang CY. 17beta-estradiol reduces cardiac hypertrophy mediated through the up-regulation of PI3K/Akt and the suppression of calcineurin/NF-AT3 signaling pathways in rats. Life Sci. 2005 Dec 12;78(4):347-56. doi: 10.1016/j.lfs.2005.04.077. Epub 2005 Sep 23. PMID: 16183079.
  16. Kuo WW, Wu CH, Lee SD, Lin JA, Chu CY, Hwang JM, Ueng KC, Chang MH, Yeh YL, Wang CJ, Liu JY, Huang CY. Second-hand smoke-induced cardiac fibrosis is related to the Fas death receptor apoptotic pathway without mitochondria-dependent pathway involvement in rats. Environ Health Perspect. 2005 Oct;113(10):1349-53. doi: 10.1289/ehp.7479. PMID: 16203245; PMCID: PMC1281278.
  17. (Correspondence Author) Huang EJ, Kuo WW, Chen YJ, Chen TH, Chang MH, Lu MC, Tzang BS, Hsu HH, Huang CY*, Lee SD*. Homocysteine and other biochemical parameters in Type 2 diabetes mellitus with different diabetic duration or diabetic retinopathy. Clin Chim Acta. 2006 Apr;366(1-2):293-8. doi: 10.1016/j.cca.2005.10.025. Epub 2005 Dec 15. PMID: 16343469.
  18. (First Author) Lee SD, Kuo WW, Lin DY, Chen TH, Kuo WH, Hsu HH, Chen JZ, Liu JY, Yeh YL, Huang CY. Role of calcineurin in Porphyromonas gingivalis-induced myocardial cell hypertrophy and apoptosis. J Biomed Sci. 2006 Mar;13(2):251-60. doi: 10.1007/s11373-005-9048-4. Epub 2005 Dec 21. PMID: 16369686.
  19. Lo MJ, Lee SD. Direct effects of IL-15 on corticosterone secretion by rat adrenocortical cells. Immunol Cell Biol. 2006 Feb;84(1):38-43. doi: 10.1111/j.1440-1711.2005.01395.x. PMID: 16405651.
  20. (First Author) Lee SD, Chen LM, Kuo WW, Shu WT, Kuo WH, Huang EJ, Tsai CC, Li PC, Liu JY, Chen TH, Huang CY. Serum insulin-like growth factor-axis and matrix metalloproteinases in patients with rheumatic arthritis or rheumatic heart disease. Clin Chim Acta. 2006 May;367(1-2):62-8. doi: 10.1016/j.cca.2005.11.015. Epub 2006 Jan 9. PMID: 16406300.
  21. (First Author): Lee SD, Wu CC, Kuo WW, Lin JA, Hwang JM, Lu MC, Chen LM, Hsu HH, Wang CK, Chang SH, Huang CY. Porphyromonas gingivalis-related cardiac cell apoptosis was majorly co-activated by p38 and extracellular signal-regulated kinase pathways. J Periodontal Res. 2006 Feb;41(1):39-46. doi: 10.1111/j.1600-0765.2005.00842.x. PMID: 16409254.
  22. Liao JM, Ting H, Lee SD, Yang CH, Liou YM, Peng ML, Tsai SJ, Lin CF, Lin TB. Electroacupuncture-induced pressor and chronotropic effects in anesthetized rats. Auton Neurosci. 2006 Jan 30;124(1-2):18-25. doi: 10.1016/j.autneu.2005.10.005. Epub 2006 Feb 3. PMID: 16459151.
  23. Liao JM, Cheng CL, Lee SD, Chen GD, Chen KJ, Yang CH, Pan SF, Chen MJ, Huang PC, Lin TB. Impaired micturition reflex caused by acute selective dorsal or ventral root(s) rhizotomy in anesthetized rats. Neurourol Urodyn. 2006;25(3):283-289. doi: 10.1002/nau.20220. PMID: 16496396.
  24. (First Author) Lee SD, Wu CC, Chang YC, Chang SH, Wu CH, Wu JP, Hwang JM, Kuo WW, Liu JY, Huang CY. Porphyromonas gingivalis-induced cellular hypertrophy and MMP-9 activity via different signaling pathways in H9c2 cardiomyoblast cells. J Periodontol. 2006 Apr;77(4):684-91. doi: 10.1902/jop.2006.050070. PMID: 16584351.
  25. Hsu HH, Cheng SF, Chen LM, Liu JY, Chu CH, Weng YJ, Li ZY, Lin CS, Lee SD, Kuo WW, Huang CY. Over-expressed estrogen receptor-alpha up-regulates hTNF-alpha gene expression and down-regulates beta-catenin signaling activity to induce the apoptosis and inhibit proliferation of LoVo colon cancer cells. Mol Cell Biochem. 2006 Sep;289(1-2):101-9. doi: 10.1007/s11010-006-9153-3. Epub 2006 Apr 21. PMID: 16628468.
  26. (First Author) Lee SD, Chang SH, Kuo WH, Ying TH, Kuo WW, Li PC, Hsu HH, Lu MC, Ting H, Huang CY. Role of mitogen-activated protein kinase kinase in Porphyromonas gingivalis-induced myocardial cell hypertrophy and apoptosis. Eur J Oral Sci. 2006 Apr;114(2):154-9. doi: 10.1111/j.1600-0722.2006.00299.x. PMID: 16630308.
  27. Huang EJ, Wu CC, Lee SD, Chen JH, Liu JY, Ko JL, Lin JA, Lu MC, Chen LM, Huang CY, Kuo WW. Opposing action of estrogen receptors alpha and beta on tumor necrosis factor-alpha gene expression and caspase-8-mediated apoptotic effects in HA22T cells. Mol Cell Biochem. 2006 Jul;287(1-2):137-45. doi: 10.1007/s11010-005-9092-4. Epub 2006 Apr 22. PMID: 16633737.
  28. Lay CS, May CM, Lee FY, Tsai YT, Lee SD, Chien S, Sinchon S. Effect of verapamil on nitric oxide synthase in a portal vein-ligated rat model: role of prostaglandin. World J Gastroenterol. 2006 Apr 21;12(15):2351-6. doi: 10.3748/wjg.v12.i15.2351. PMID: 16688824; PMCID: PMC4088069.
  29. (Co-Correspondence Author) Kuo WW, Liu CJ, Chen LM, Wu CH, Chu CH, Liu JY, Lu MC, Lin JA, Lee SD*, Huang CY*. Cardiomyoblast apoptosis induced by insulin-like growth factor (IGF)-I resistance is IGF-II dependent and synergistically enhanced by angiotensin II. Apoptosis. 2006 Jul;11(7):1075-89. doi: 10.1007/s10495-006-7028-4. PMID: 16699953.
  30. (First Author) Lee SD, Huang CY, Shu WT, Chen TH, Lin JA, Hsu HH, Lin CS, Liu CJ, Kuo WW, Chen LM. Pro-inflammatory states and IGF-I level in ischemic heart disease with low or high serum iron. Clin Chim Acta. 2006 Aug;370(1-2):50-6. doi: 10.1016/j.cca.2006.01.012. Epub 2006 Jun 21. PMID: 16793032.
  31. (First Author) Lee SD, Chu CH, Huang EJ, Lu MC, Liu JY, Liu CJ, Hsu HH, Lin JA, Kuo WW, Huang CY. Roles of insulin-like growth factor II in cardiomyoblast apoptosis and in hypertensive rat heart with abdominal aorta ligation. Am J Physiol Endocrinol Metab. 2006 Aug;291(2):E306-14. doi: 10.1152/ajpendo.00127.2005. PMID: 16825605.
  32. Jong GP, Ma T, Chou P, Chang MH, Wu CH, Lis PC, Lee SD, Liu JY, Kuo WW, Huang CY. Serum MMP-9 activity as a diagnosing marker for the developing heart failure of post MI patients. Chin J Physiol. 2006 Apr 30;49(2):104-9. Erratum in: Chin J Physiol. 2006 Jun 30;49(3):167. PMID: 16830792.
  33. Hsu HH, Cheng SF, Wu CC, Chu CH, Weng YJ, Lin CS, Lee SD, Wu HC, Huang CY, Kuo WW. Apoptotic effects of over-expressed estrogen receptor-beta on LoVo colon cancer cell is mediated by p53 signalings in a ligand-dependent manner. Chin J Physiol. 2006 Apr 30;49(2):110-6. Erratum in: Chin J Physiol. 2006 Jun 30;49(3):167. PMID: 16830793.
  34. (First Author) Lee SD, Kuo WW, Lin JA, Chu YF, Wang CK, Yeh YL, Wang SG, Liu JY, Chang MH, Huang CY. Effects of long-term intermittent hypoxia on mitochondrial and Fas death receptor dependent apoptotic pathways in rat hearts. Int J Cardiol. 2007 Apr 4;116(3):348-56. doi: 10.1016/j.ijcard.2006.03.064. Epub 2006 Jul 21. PMID: 16859770.
  35. (Correspondence Author) Yang AL, Su CT, Lin KL, Chao JI, You HP, Lee SD. Exercise training improves insulin-induced and insulin-like growth factor-1-induced vasorelaxation in rat aortas. Life Sci. 2006 Oct 19;79(21):2017-21. doi: 10.1016/j.lfs.2006.06.037. Epub 2006 Jun 29. PMID: 16889802.
  36. Tsai MC, Tang CY, Chang YT, Cheng CL, Liao JM, Lee SD, Pan SF, Chen MJ, Huang PC, Lin TB. Effects of selective unilateral dorsal root(s) rhizotomy on micturition reflex in anesthetized rats. Neurourol Urodyn. 2006;25(7):820-7. doi: 10.1002/nau.20211. PMID: 16917937.
  37. Huang EJ, Wu CC, Huang HP, Liu JY, Lin CS, Chang YZ, Lin JA, Lin JG, Chen LM, Lee SD, Kuo WW, Huang CY. Apoptotic and anti-proliferative effects of 17beta-estradiol and 17beta-estradiol-like compounds in the Hep3B cell line. Mol Cell Biochem. 2006 Oct;290(1-2):1-7. doi: 10.1007/s11010-005-9000-y. Epub 2006 Aug 19. PMID: 16924424.
  38. (Correspondence Author) Yang AL, Lo MJ, Ting H, Chen JS, Huang CY, Lee SD. GABA(A) and GABA(B) receptors differentially modulate volume and frequency in ventilatory compensation in obese Zucker rats. J Appl Physiol (1985). 2007 Jan;102(1):350-7. doi: 10.1152/japplphysiol.01463.2005. Epub 2006 Sep 21. PMID: 16990497.
  39. (Correspondence Author) Chen LM, Kuo WW, Yang JJ, Wang SG, Yeh YL, Tsai FJ, Ho YJ, Chang MH, Huang CY*, Lee SD*. Eccentric cardiac hypertrophy was induced by long-term intermittent hypoxia in rats. Exp Physiol. 2007 Mar;92(2):409-16. doi: 10.1113/expphysiol.2006.036590. Epub 2006 Dec 21. PMID: 17185350.
  40. Yang AL, Lee SD, Su CT, Wang JL, Lin KL. Effects of exercise intervention on patients with stroke with prior coronary artery disease: aerobic capacity, functional ability, and lipid profile: a pilot study. J Rehabil Med. 2007 Jan;39(1):88-90. doi: 10.2340/16501977-0021. PMID: 17225044.
  41. Chang MH, Kuo WW, Li PC, Lin DY, Lee SD, Tsai FJ, Jong GP, Lin YM, Huang CY, Wu WJ. Down regulation of IGF-I and IGF-IR gene expression in right atria tissue of ventricular septal defect infants with right atria hypoxemia. Clin Chim Acta. 2007 Apr;379(1-2):81-6. doi: 10.1016/j.cca.2006.12.021. Epub 2007 Jan 10. PMID: 17300770.
  42. (Correspondence Author) Wu MK, Wang CK, Bai YM, Huang CY, Lee SD*. Outcomes of obese, clozapine- treated inpatients with schizophrenia placed on a six-month diet and physical activity program. Psychiatr Serv. 2007 Apr;58(4):544-50. doi: 10.1176/ps.2007.58.4.544. PMID: 17412858.
  43. (Co-Correspondence Author) Wu HC, Yeh YL, Kuo WW, Huang SK, Kuo WH, Hsieh DJ, Wu CL, Tsai CH, Lee SD*, Huang CY*. P38 mitogen-activated protein kinase pathways are involved in the hypertrophy and apoptosis of cardiomyocytes induced by Porphyromonas gingivalis conditioned medium. Cell Biochem Funct. 2008 Mar-Apr;26(2):246-55. doi: 10.1002/cbf.1443. PMID: 17894423.
  44. (First Author) Lee SD, Tzang BS, Kuo WW, Lin YM, Yang AL, Chen SH, Tsai FJ, Wu FL, Lu MC, Huang CY. Cardiac fas receptor-dependent apoptotic pathway in obese Zucker rats. Obesity (Silver Spring). 2007 Oct;15(10):2407-15. doi: 10.1038/oby.2007.286. PMID: 17925466.
  45. Chen GD, Peng ML, Wang PY, Lee SD, Chang HM, Pan SF, Chen MJ, Tung KC, Lai CY, Lin TB. Calcium/calmodulin-dependent kinase II mediates NO-elicited PKG activation to participate in spinal reflex potentiation in anesthetized rats. Am J Physiol Regul Integr Comp Physiol. 2008 Feb;294(2):R487-93. doi: 10.1152/ajpregu.00600.2007. Epub 2007 Nov 28. PMID: 18046020.
  46. (Correspondence Author) Lu MC, Tzang BS, Kuo WW, Wu FL, Chen YS, Tsai CH, Huang CY, Lee SD*. More activated cardiac mitochondrial-dependent apoptotic pathway in obese Zucker rats. Obesity (Silver Spring). 2007 Nov;15(11):2634-42. doi: 10.1038/oby.2007.315. PMID: 18070754.
  47. Peng HY, Cheng YW, Lee SD, Ho YC, Chou D, Chen GD, Cheng CL, Hsu TH, Tung KC, Lin TB. Glutamate-mediated spinal reflex potentiation involves ERK 1/2 phosphorylation in anesthetized rats. Neuropharmacology. 2008 Mar;54(4):686-98. doi: 10.1016/j.neuropharm.2007.11.017. Epub 2007 Dec 5. PMID: 18191957.
  48. (First Author) Lee SD, Kuo WW, Bau DT, Ko FY, Wu FL, Kuo CH, Tsai FJ, Wang PS, Lu MC, Huang CY. The coexistence of nocturnal sustained hypoxia and obesity additively increases cardiac apoptosis. J Appl Physiol (1985). 2008 Apr;104(4):1144-53. doi: 10.1152/japplphysiol.00152.2007. Epub 2008 Jan 17. PMID: 18202171.
  49. Pan SF, Peng HY, Chen CC, Chen MJ, Lee SD, Cheng CL, Shyu JC, Liao JM, Chen GD, Lin TB. Nicotine-activated descending facilitation on spinal NMDA-dependent reflex potentiation from pontine tegmentum in rats. Am J Physiol Renal Physiol. 2008 May;294(5):F1195-204. doi: 10.1152/ajprenal.00539.2007. Epub 2008 Feb 20. PMID: 18287401.
  50. (Correspondence Author) Jong GP, Wang YF, Tsai FJ, Tsai CH, Wu CL, Liu RH, Hsieh DJ, Ko FY, Huang CY, Lee SD*. Immunoglobulin E and matrix metalloproteinase-9 in patients with different stages of coronary artery diseases. Chin J Physiol. 2007 Dec 31;50(6):277-82. PMID: 18442010.
  51. Peng HY, Chang HM, Chang SY, Tung KC, Lee SD, Chou D, Lai CY, Chiu CH, Chen GD, Lin TB. Orexin-A modulates glutamatergic NMDA-dependent spinal reflex potentiation via inhibition of NR2B subunit. Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E117-29. doi: 10.1152/ajpendo.90243.2008. Epub 2008 May 13. PMID: 18477704.
  52. (Correspondence Author) Wu MK, Huang CY, Liou YJ, Wang CK, Lee SD. Glucose-insulin homeostasis, lipid profiles and GH-IGF-IGFBP axis in clozapine-treated schizophrenic obesity versus non-psychiatric obesity. Int J Obes (Lond). 2008 Mar;32(3):436-42. doi: 10.1038/sj.ijo.0803750. Epub 2007 Oct 23. PMID: 17955031.
  53. Liu TC, Liu YY, Lee SD, Huang CY, Chien KY, Cheng IS, Lin CY, Kuo CH. Effects of short-term detraining on measures of obesity and glucose tolerance in elite athletes. J Sports Sci. 2008 Jul;26(9):919-25. doi: 10.1080/02640410801885925. PMID: 18569557.
  54. Peng HY, Huang PC, Liao JM, Tung KC, Lee SD, Cheng CL, Shyu JC, Lai CY, Chen GD, Lin TB. Estrous cycle variation of TRPV1-mediated cross-organ sensitization between uterus and NMDA-dependent pelvic-urethra reflex activity. Am J Physiol Endocrinol Metab. 2008 Sep;295(3):E559-68. doi: 10.1152/ajpendo.90289.2008. Epub 2008 Jun 24. PMID: 18577691.
  55. Peng HY, Chang HM, Lee SD, Huang PC, Chen GD, Lai CH, Lai CY, Chiu CH, Tung KC, Lin TB. TRPV1 mediates the uterine capsaicin-induced NMDA NR2B-dependent cross-organ reflex sensitization in anesthetized rats. Am J Physiol Renal Physiol. 2008 Nov;295(5):F1324-35. doi: 10.1152/ajprenal.00126.2008. Epub 2008 Jul 16. PMID: 18632800.
  56. (Correspondence Author) Yang AL, Su CT, Lin KL, Lee SD*. Enhancement of vascular function mediated by insulin and insulin-like growth factor-1 following single exercise session. Chin J Physiol. 2008 Apr 30;51(2):71-7. Erratum in: Chin J Physiol. 2008 Jun 30;51(3):196. PMID: 18666709.
  57. (First Author) Lee SD, Kuo WW, Ho YJ, Lin AC, Tsai CH, Wang HF, Kuo CH, Yang AL, Huang CY, Hwang JM. Cardiac Fas-dependent and mitochondria-dependent apoptosis in ovariectomized rats. Maturitas. 2008 Nov 20;61(3):268-77. doi: 10.1016/j.maturitas.2008.07.004. Epub 2008 Oct 31. PMID: 18951737.
  58. (Correspondence Author) Ting H, Lo HS, Chang SY, Chung AH, Kuan PC, Yuan SC, Huang CN, Lee SD. Post- to pre-overnight sleep systolic blood pressures are associated with sleep respiratory disturbance, pro-inflammatory state and metabolic situation in patients with sleep-disordered breathing. Sleep Med. 2009 Aug;10(7):720-5. doi: 10.1016/j.sleep.2008.07.010. Epub 2008 Oct 25. PMID: 18952496.
  59. (Correspondence Author) Cheng YC, Kuo WW, Wu CH, Shu WT, Kuo CH, Hwang JM, Hsu HH, Chen LM, Huang CY, Lee SD*. Iron status and cardiovascular risk factors in patients with haemodialysis versus patients with ischaemic heart disease. Nephrology (Carlton). 2009 Feb;14(1):65-9. doi: 10.1111/j.1440-1797.2008.01004.x. Epub 2008 Dec 2. PMID: 19054334.
  60. Wang HT, Chen SM, Lee SD, Hsu MC, Chen KN, Liou YF, Kuo CH. The role of DHEA-S in the mood adjustment against negative competition outcome in golfers. J Sports Sci. 2009 Feb 1;27(3):291-7. doi: 10.1080/02640410802520810. PMID: 19156586.
  61. Peng HY, Chen GD, Tung KC, Lai CY, Hsien MC, Chiu CH, Lu HT, Liao JM, Lee SD, Lin TB. Colon mustard oil instillation induced cross-organ reflex sensitization on the pelvic-urethra reflex activity in rats. Pain. 2009 Mar;142(1-2):75-88. doi: 10.1016/j.pain.2008.11.017. Epub 2009 Jan 23. PMID: 19167822.
  62. Hsu TH, Liu YF, Lee SD, Chen SM, Lee JP, Fang CL, Liu TC, Kuo CH. Suppression of age-dependent increase in insulinemia in early middle-aged females with exercise habit. Chin J Physiol. 2008 Oct 31;51(5):263-8. PMID: 19175181.
  63. (Correspondence Author) Lin YM, Huang SK, Wang HF, Chen LM, Tsai FJ, Hsu HH, Kuo CH, Wang PS, Huang CY, Lee SD*. Short-term versus long-term intermittent hypobaric hypoxia on cardiac fibrosis and Fas death receptor dependent apoptotic pathway in rat hearts. Chin J Physiol. 2008 Oct 31;51(5):308-16. PMID: 19175187.
  64. Peng HY, Chen GD, Lee SD, Lai CY, Chiu CH, Cheng CL, Chang YS, Hsieh MC, Tung KC, Lin TB. Neuroactive steroids inhibit spinal reflex potentiation by selectively enhancing specific spinal GABA(A) receptor subtypes. Pain. 2009 May;143(1-2):12-20. doi: 10.1016/j.pain.2008.12.023. Epub 2009 Feb 27. PMID: 19250751.
  65. Chen CH, Liu YF, Lee SD, Huang CY, Lee WC, Tsai YL, Hou CW, Chan YS, Kuo CH. Altitude hypoxia increases glucose uptake in human heart. High Alt Med Biol. 2009 Spring;10(1):83-6. doi: 10.1089/ham.2008.1064. PMID: 19278356.
  66. Ho CT, Su CL, Chen MT, Liou YF, Lee SD, Chien KY, Kuo CH. Aging effects on glycemic control and inflammation for politicians in Taiwan. Chin J Physiol. 2008 Dec 31;51(6):402-7. Erratum in: Chin J Physiol. 2009 Feb 28;52(1):57. PMID: 19280885.
  67. (Co-first Author#) Peng HY#, Chen GD, Tung KC, Chien YW, Lai CY, Hsieh MC, Chiu CH, Lai CH, Lee SD#, Lin TB. Estrogen-dependent facilitation on spinal reflex potentiation involves the Cdk5/ERK1/2/NR2B cascade in anesthetized rats. Am J Physiol Endocrinol Metab. 2009 Aug;297(2):E416-26. doi: 10.1152/ajpendo.00129.2009. Epub 2009 Jun 16. PMID: 19531642.
  68. Wang JS, Chen SM, Lee SP, Lee SD, Huang CY, Hsieh CC, Kuo CH. Dehydroepiandrosterone sulfate linked to physiologic response against hot spring immersion. Steroids. 2009 Nov;74(12):945-9. doi: 10.1016/j.steroids.2009.06.011. Epub 2009 Jul 10. PMID: 19595697.
  69. Chen YL, Huang CY, Lee SD, Chou SW, Hsieh PS, Hsieh CC, Huang YG, Kuo CH. Discipline-specific insulin sensitivity in athletes. Nutrition. 2009 Nov- Dec;25(11-12):1137-42. doi: 10.1016/j.nut.2009.03.003. Epub 2009 Jul 12. PMID: 19596184.
  70. (Co-Correspondence Author) Kuo WW, Huang CY, Chung JG, Yang SF, Tsai KL, Chiu TH, Lee SD*, Ou HC*. Crude extracts of Solanum lyratum protect endothelial cells against oxidized low- density lipoprotein-induced injury by direct antioxidant action. J Vasc Surg. 2009 Oct;50(4):849-60. doi: 10.1016/j.jvs.2009.06.046. Epub 2009 Aug 22. PMID: 19703745.
  71. (Correspondence Author) Kuo WW, Chung LC, Liu CT, Wu SP, Kuo CH, Tsai FJ, Tsai CH, Lu MC, Huang CY, Lee SD*. Effects of insulin replacement on cardiac apoptotic and survival pathways in streptozotocin-induced diabetic rats. Cell Biochem Funct. 2009 Oct;27(7):479-87. doi: 10.1002/cbf.1601. PMID: 19718675.
  72. Lee WJ, Ou HC, Wu CM, Lee IT, Lin SY, Lin LY, Tsai KL, Lee SD, Sheu WH. Sesamin mitigates inflammation and oxidative stress in endothelial cells exposed to oxidized low-density lipoprotein. J Agric Food Chem. 2009 Dec 9;57(23):11406-17. doi: 10.1021/jf902876p. PMID: 19951001.
  73. Ting H, Wong RH, Yang HJ, Lee SP, Lee SD, Wang L. Sleep-disordered breathing, behavior, and academic performance in Taiwan schoolchildren. Sleep Breath. 2011 Jan;15(1):91-8. doi: 10.1007/s11325-010-0329-4. Epub 2010 Feb 2. PMID: 20119852.
  74. (Correspondence Author) Yang AL, Yeh CK, Su CT, Lo CW, Lin KL, Lee SD*. Aerobic exercise acutely improves insulin- and insulin-like growth factor-1-mediated vasorelaxation in hypertensive rats. Exp Physiol. 2010 May;95(5):622-9. doi: 10.1113/expphysiol.2009.050146. Epub 2010 Feb 5. PMID: 20139168.
  75. Lin WY, Huang HY, Liu CS, Li CI, Lee SD, Lin CC, Huang KC. A hospital-based multidisciplinary approach improves nutritional status of the elderly living in long-term care facilities in middle Taiwan. Arch Gerontol Geriatr. 2010 Feb;50 Suppl 1:S22-6. doi: 10.1016/S0167-4943(10)70007-8. PMID: 20171451.
  76. Chen YL, Liu YF, Huang CY, Lee SD, Chan YS, Chen CC, Harris B, Kuo CH. Normalization effect of sports training on blood pressure in hypertensives. J Sports Sci. 2010 Feb;28(4):361-7. doi: 10.1080/02640410903508862. PMID: 20175014.
  77. Chen CY, Tsai YL, Kao CL, Lee SD, Wu MC, Mallikarjuna K, Liao YH, Ivy JL, Kuo CH. Effect of mild intermittent hypoxia on glucose tolerance, muscle morphology and AMPK-PGC-1alpha signaling. Chin J Physiol. 2010 Feb 28;53(1):62-71. doi: 10.4077/cjp.2010.amk078. PMID: 21789886.
  78. (Correspondence Author) Ou HC, Song TY, Yeh YC, Huang CY, Yang SF, Chiu TH, Tsai KL, Chen KL, Wu YJ, Tsai CS, Chang LY, Kuo WW, Lee SD*. EGCG protects against oxidized LDL-induced endothelial dysfunction by inhibiting LOX-1-mediated signaling. J Appl Physiol (1985). 2010 Jun;108(6):1745-56. doi: 10.1152/japplphysiol.00879.2009. Epub 2010 Mar 4. PMID: 20203069.
  79. Chan YS, Hsu KY, Kuo CH, Lee SD, Chen SC, Chen WJ, Ueng SW. Using low- intensity pulsed ultrasound to improve muscle healing after laceration injury: an in vitro and in vivo study. Ultrasound Med Biol. 2010 May;36(5):743-51. doi: 10.1016/j.ultrasmedbio.2010.02.010. Epub 2010 Apr 9. PMID: 20381949.
  80. Liu SP, Lee SD, Lee HT, Liu DD, Wang HJ, Liu RS, Lin SZ, Su CY, Li H, Shyu WC. Granulocyte colony-stimulating factor activating HIF-1alpha acts synergistically with erythropoietin to promote tissue plasticity. PLoS One. 2010 Apr 9;5(4):e10093. doi: 10.1371/journal.pone.0010093. Erratum in: PLoS One. 2010;5(10). doi:10.1371/annotation/433064f4-e30a-4000-8e5a-9e8d1775d820. Su, Ching-Yuan [added]; Li, Hung [added]. PMID: 20404921; PMCID: PMC2852409.
  81. (Correspondence Author) Chen JS, Wang HJ, Chang WC, Jao CC, Wu BT, Shyu WC, Lee SD. Altered nitroxidergic and NMDA receptor-mediated modulation of baroreflex-mediated heart rate in obese Zucker rats. Hypertens Res. 2010 Sep;33(9):932-6. doi: 10.1038/hr.2010.109. Epub 2010 Jun 17. PMID: 20555326.
  82. Ou HC, Lee WJ, Lee SD, Huang CY, Chiu TH, Tsai KL, Hsu WC, Sheu WH. Ellagic acid protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway. Toxicol Appl Pharmacol. 2010 Oct 15;248(2):134-43. doi: 10.1016/j.taap.2010.07.025. Epub 2010 Aug 4. PMID: 20691200.
  83. (Correspondence Author) Liou CM, Yang AL, Kuo CH, Tin H, Huang CY, Lee SD*. Effects of 17beta- estradiol on cardiac apoptosis in ovariectomized rats. Cell Biochem Funct. 2010 Aug;28(6):521-8. doi: 10.1002/cbf.1687. PMID: 20803709.
  84. (First Author) Lee SD, Lo MJ. Ginsenoside Rb1 promotes PC12 cell cycle kinetics through an adenylate cyclase-dependent protein kinase A pathway. Nutr Res. 2010 Sep;30(9):660-6. doi: 10.1016/j.nutres.2010.09.002. PMID: 20934608.
  85. Chen MT, Lee WC, Chen SC, Chen CC, Chen CY, Lee SD, Jensen J, Kuo CH. Effect of a prolonged altitude expedition on glucose tolerance and abdominal fatness. Res Q Exerc Sport. 2010 Dec;81(4):472-7. doi: 10.1080/02701367.2010.10599708. PMID: 21268471.
  86. Chen YL, Yeh DP, Lee SD, Chia-Hua Kuo CH. Regression to the mean: Error reduction versus blood pressure normalization by sports training. Journal of Sports Sciences. 29(6): 645-647, 2011 March. https://doi.org/10.1080/02640414.2010.547210 Letter To The Editor. 
  87. Chen JL, Yeh DP, Lee JP, Chen CY, Huang CY, Lee SD, Chen CC, Kuo TB, Kao CL, Kuo CH. Parasympathetic nervous activity mirrors recovery status in weightlifting performance after training. J Strength Cond Res. 2011 Jun;25(6):1546-52. doi: 10.1519/JSC.0b013e3181da7858. PMID: 21273908.
  88. Chen YC, Lee SD, Hsih SY, Hsu YP, Kuo CH, Ho LT. Perturbations of the stress-induced GLUT4 localization pathway in slow-twitch muscles of obese Zucker rats. J Physiol Biochem. 2011 Sep;67(3):297-305. doi: 10.1007/s13105-011-0075-5. Epub 2011 Feb 24. PMID: 21347724.
  89. Cheng YY, Kuo CH, Hsieh WL, Lee SD, Lee WJ, Chen LK, Kao CL. Anxiety, depression and quality of life (QoL) in patients with chronic dizziness. Arch Gerontol Geriatr. 2012 Jan-Feb;54(1):131-5. doi: 10.1016/j.archger.2011.04.007. Epub 2011 May 11. PMID: 21561671.
  90. Chen HH, Chen YL, Huang CY, Lee SD, Chen SC, Kuo CH. Effects of one-year swimming training on blood pressure and insulin sensitivity in mild hypertensive young patients. Chin J Physiol. 2010 Jun 30;53(3):185-9. doi: 10.4077/cjp.2010.amk042. PMID: 21793327.
  91. Wu CY, Chuang LL, Lin KC, Lee SD, Hong WH. Responsiveness, minimal detectable change, and minimal clinically important difference of the Nottingham Extended Activities of Daily Living Scale in patients with improved performance after stroke rehabilitation. Arch Phys Med Rehabil. 2011 Aug;92(8):1281-7. doi: 10.1016/j.apmr.2011.03.008. PMID: 21807147.
  92. Tzeng CY, Lai YC, Hou CW, Chen CY, Lee SD, Huang CY, Chen CC, Liu TC, Liu YF, Kao CL, Kuo CH. IGF-1 partially reproduces beneficial effect of exercise training on glucose tolerance in normal rats. Adaptive Medicine, 3(2), 112-118, 2011 Aug.
  93. Cheng IS, Huang SW, Lu HC, Wu CL, Chu YC, Lee SD, Huang CY, Kuo CH. Oral hydroxycitrate supplementation enhances glycogen synthesis in exercised human skeletal muscle. Br J Nutr. 2012 Apr;107(7):1048-55. doi: 10.1017/S0007114511003862. Epub 2011 Aug 9. PMID: 21824444.
  94. Korivi M, Hou CW, Huang CY, Lee SD, Hsu MF, Yu SH, Chen CY, Liu YY, Kuo CH. Ginsenoside-Rg1 Protects the Liver against Exhaustive Exercise-Induced Oxidative Stress in Rats. Evid Based Complement Alternat Med. 2012;2012:932165. doi: 10.1155/2012/932165. Epub 2011 Sep 20. PMID: 21941591; PMCID: PMC3176525.
  95. Huang PI, Chou YC, Chang YL, Chien Y, Chen KH, Song WS, Peng CH, Chang CH, Lee SD, Lu KH, Chen YJ, Kuo CH, Hsu CC, Lee HC, Yung MC. Enhanced differentiation of three-gene-reprogrammed induced pluripotent stem cells into adipocytes via adenoviral-mediated PGC-1α overexpression. Int J Mol Sci. 2011;12(11):7554-68. doi: 10.3390/ijms12117554. Epub 2011 Nov 7. PMID: 22174616; PMCID: PMC3233422.
  96. Chen YC, Lee SD, Kuo CH, Ho LT. The effects of altitude training on the AMPK-related glucose transport pathway in the red skeletal muscle of both lean and obese Zucker rats. High Alt Med Biol. 2011 Winter;12(4):371-8. doi: 10.1089/ham.2010.1088. PMID: 22206563; PMCID: PMC3248611.
  97. (Correspondence Author) Huang CY, Yang AL, Lin YM, Wu FN, Lin JA, Chan YS, Tsai FJ, Tsai CH, Kuo CH, Lee SD. Anti-apoptotic and pro-survival effects of exercise training on hypertensive hearts. J Appl Physiol (1985). 2012 Mar;112(5):883-91. doi: 10.1152/japplphysiol.00605.2011. Epub 2011 Dec 29. PMID: 22207725.
  98. (Correspondence Author) Ting H, Huang RJ, Lo HS, Chung AH, Chang SY, Wang L, Lee SP, Lee SD*. Vanished gender differences of cardiometabolic risk factors after matching the apnea hypopnea index at postmenopausal age. Gend Med. 2012 Feb;9(1):9-20. doi: 10.1016/j.genm.2011.12.001. Epub 2012 Jan 25. PMID: 22277661.
  99. (Correspondence Author) Cheng SM, Ho TJ, Yang AL, Chen IJ, Kao CL, Wu FN, Lin JA, Kuo CH, Ou HC, Huang CY, Lee SD*. Exercise training enhances cardiac IGFI-R/PI3K/Akt and Bcl-2 family associated pro-survival pathways in streptozotocin-induced diabetic rats. Int J Cardiol. 2013 Jul 31;167(2):478-85. doi: 10.1016/j.ijcard.2012.01.031. Epub 2012 Feb 17. PMID: 22341695.
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  101. Chen SC, Liao CA, Lee SD, Chen YL, Lin CT, Kao CL, Kuo CH. Cross-generation link between inactive behavior of schoolchildren and metabolic disease category of parents. Chin J Physiol. 2012 Apr 30;55(2):108-13. doi: 10.4077/CJP.2012.BAA007. PMID: 22559735.
  102. (Correspondence Author) Huang CY, Lee SD* Possible pathophysiology of heart failure in obesity: Cardiac apoptosis. BioMedicine, 2(1), 36-40.
  103. (Co-Correspondence Author) Liao YH, Liao KF, Kao CL, Chen CY, Huang CY, Chang WH, Ivy JL, Bernard JR, Lee SD*, Kuo CH*. Effect of dehydroepiandrosterone administration on recovery from mix-type exercise training-induced muscle damage. Eur J Appl Physiol. 2013 Jan;113(1):99-107. doi: 10.1007/s00421-012-2409-6. Epub 2012 May 16. PMID: 22588361.
  104. (Co-Correspondence Author) Yu SH, Huang HY, Korivi M, Hsu MF, Huang CY, Hou CW, Chen CY, Kao CL, Lee RP, Lee SD*, Kuo CH*. Oral Rg1 supplementation strengthens antioxidant defense system against exercise-induced oxidative stress in rat skeletal muscles. J Int Soc Sports Nutr. 2012 May 18;9(1):23. doi: 10.1186/1550-2783-9-23. PMID: 22607394; PMCID: PMC3469378.
  105. Tseng CY, Lee JP, Tsai YS, Lee SD, Kao CL, Liu TC, Lai C, Harris MB, Kuo CH. Topical cooling (icing) delays recovery from eccentric exercise-induced muscle damage. J Strength Cond Res. 2013 May;27(5):1354-61. doi: 10.1519/JSC.0b013e318267a22c. PMID: 22820210.
  106. Lee SP, Su HK, Lee SD. Effects of computer-based immediate feedback on foreign language listening comprehension and test-associated anxiety. Percept Mot Skills. 2012 Jun;114(3):995-1006. doi: 10.2466/28.11.21.PMS.114.3.995-1006. PMID: 22913036.
  107. (Correspondence Author) Ou HC, Hsieh YL, Yang NC, Tsai KL, Chen KL, Tsai CS, Chen IJ, Wu BT, Lee SD*. Ginkgo biloba extract attenuates oxLDL-induced endothelial dysfunction via an AMPK-dependent mechanism. J Appl Physiol (1985). 2013 Jan 15;114(2):274-85. doi: 10.1152/japplphysiol.00367.2012. Epub 2012 Nov 29. PMID: 23195633.
  108. Wang HC, Tsai JC, Chao YF, Chung MH, Yu YH, Chiu KL, Lee SD. An exploration of beliefs regarding exercise among Taiwanese patients with chronic obstructive pulmonary disease. Heart Lung. 2013 Mar-Apr;42(2):133-8. doi: 10.1016/j.hrtlng.2012.12.004. Epub 2013 Jan 4. PMID: 23290711.
  109. Chia M, Liao CA, Huang CY, Lee WC, Hou CW, Yu SH, Harris MB, Hsu TS, Lee SD, Kuo CH. Reducing body fat with altitude hypoxia training in swimmers: role of blood perfusion to skeletal muscles. Chin J Physiol. 2013 Feb 28;56(1):18-25. doi: 10.4077/CJP.2013.BAA071. PMID: 23347012.
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  114. Wang HC, Chao YF, Tsai JC, Chung MH, Yu YH, Hang LW, Lee SD. Development and preliminary validation of a questionnaire on regular exercise beliefs among patients with chronic obstructive pulmonary disease. J Clin Nurs. 2014 Apr;23(7-8):1133-43. doi: 10.1111/jocn.12300. Epub 2013 Sep 5. PMID: 24033794.
  115. Cheng YY, Leu HB, Chen TJ, Chen CL, Kuo CH, Lee SD, Kao CL. Metformin- inclusive therapy reduces the risk of stroke in patients with diabetes: a 4-year follow-up study. J Stroke Cerebrovasc Dis. 2014 Feb;23(2):e99-105. doi: 10.1016/j.jstrokecerebrovasdis.2013.09.001. Epub 2013 Oct 9. PMID: 24119365.
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  118. Kao CL, Tsai KL, Cheng YY, Kuo CH, Lee SD, Chan RC. Vestibular rehabilitation ameliorates chronic dizziness through the SIRT1 axis. Front Aging Neurosci. 2014 Mar 4;6:27. doi: 10.3389/fnagi.2014.00027. PMID: 24624081; PMCID: PMC3941041.
  119. (Correspondence Author) Cheng YJ, Cheng SM, Teng YH, Shyu WC, Chen HL, Lee SD. Cordyceps sinensis prevents apoptosis in mouse liver with D-galactosamine/lipopolysaccharide- induced fulminant hepatic failure. Am J Chin Med. 2014;42(2):427-41. doi: 10.1142/S0192415X14500281. PMID: 24707872.
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  121. (Correspondence Author) Ting H, Huang RJ, Lai CH, Chang SW, Chung AH, Kuo TY, Chang CH, Shih TS, Lee SD*. Evaluation of candidate measures for home-based screening of sleep disordered breathing in Taiwanese bus drivers. Sensors (Basel). 2014 May 5;14(5):8126-49. doi: 10.3390/s140508126. PMID: 24803198; PMCID: PMC4063033.
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  125. (Correspondence Author) Teng YK, Chiang LC, Lue KH, Chang SW, Wang L, Lee SP, Ting H, Lee SD. Poor sleep quality measured by polysomnography in non-obese asthmatic children with or without moderate to severe obstructive sleep apnea. Sleep Med. 2014 Sep;15(9):1062-7. doi: 10.1016/j.sleep.2014.04.017. Epub 2014 Jun 6. PMID: 25018024.
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  128. Hung CC, Liao CC, Wu PL, Lee SD, Lane HY. Metabolic Abnormality and Sleep Disturbance are Associated with Clinical Severity of Patients with Schizophrenia. Biomedicine (Taipei). 2014;4(1):6. doi: 10.7603/s40681-014-0006-1. Epub 2014 Aug 6. PMID: 25520919; PMCID: PMC4265018.
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  131. (Correspondence Author) Wu BT, Chiang MC, Tasi CY, Kuo CH, Shyu WC, Kao CL, Huang CY, Lee SD*. Cardiac Fas-Dependent and Mitochondria-Dependent Apoptotic Pathways in a Transgenic Mouse Model of Huntington's Disease. Cardiovasc Toxicol. 2016 Apr;16(2):111-21. doi: 10.1007/s12012-015-9318-y. PMID: 25800750.
  132. (Correspondence Author) Ting H, Liou CM, Shih TS, Wang CH, Chang SY, Chung AH, Lee JF, Wang L, Huang RJ, Lee SD*. Obstructive sleep apnea rather than diabetes or obesity associated with proteinuria in late mid-aged male workers: a decision tree analysis. Sleep Breath. 2015 Dec;19(4):1167-74. doi: 10.1007/s11325-015-1132-z. Epub 2015 Feb 10. PMID: 25876173.
  133. Lee SP, Lee SD, Liao YL, Wang AC. Effects of audio-visual aids on foreign language test anxiety, reading and listening comprehension, and retention in EFL learners. Percept Mot Skills. 2015 Apr;120(2):576-90. doi: 10.2466/24.PMS.120v14x2. PMID: 25914939.
  134. Huang CY, Hsu TC, Kuo WW, Liou YF, Lee SD, Ju DT, Kuo CH, Tzang BS. The Root Extract of Gentiana macrophylla Pall. Alleviates Cardiac Apoptosis in Lupus Prone Mice. PLoS One. 2015 May 18;10(5):e0127440. doi: 10.1371/journal.pone.0127440. PMID: 25985203; PMCID: PMC4436133.
  135. (Correspondence Author) Lai MC, Lin JG, Pai PY, Lai MH, Lin YM, Yeh YL, Cheng SM, Liu YF, Huang CY*, Lee SD*. Effects of rhodiola crenulata on mice hearts under severe sleep apnea. BMC Complement Altern Med. 2015 Jun 25;15:198. doi: 10.1186/s12906-015-0698-0. PMID: 26108210; PMCID: PMC4479239.
  136. Lin YY, Lee SD, Su CT, Cheng TL, Yang AL. Long-term treadmill training ameliorates endothelium-dependent vasorelaxation mediated by insulin and insulin-like growth factor-1 in hypertension. J Appl Physiol (1985). 2015 Sep 15;119(6):663-9. doi: 10.1152/japplphysiol.01062.2014. Epub 2015 Jul 16. PMID: 26183483.
  137. (Co-Correspondence Author) Chang WH, Tsai YL, Huang CY, Hsieh CC, Chaunchaiyakul R, Fang Y, Lee SD, Kuo CH. Null effect of ginsenoside Rb1 on improving glycemic status in men during a resistance training recovery. J Int Soc Sports Nutr. 2015 Aug 20;12:34. doi: 10.1186/s12970-015-0095-6. PMID: 26300710; PMCID: PMC4545376.
  138. (Correspondence Author) Pai P, Lai CJ, Lin CY, Liou YF, Huang CY, Lee SD. Effect of superoxide anion scavenger on rat hearts with chronic intermittent hypoxia. J Appl Physiol (1985). 2016 Apr 15;120(8):982-90. doi: 10.1152/japplphysiol.01109.2014. Epub 2016 Jan 14. PMID: 26769958.
  139. (Co-First Author) Huang RJ#, Lai CH#, Lee SD#, Wang WC, Tseng LH, Chen YP, Chang SW, Chung AH, Ting H. Scaling exponent values as an ordinary function of the ratio of very low frequency to high frequency powers in heart rate variability over various sleep stages. Sleep Breath. 2016 Sep;20(3):975-85. doi: 10.1007/s11325-016-1320-5. Epub 2016 Apr 2. PMID: 27039097.
  140. (Correspondence Author) Lin YY, Hsieh PS, Cheng YJ, Cheng SM, Chen CJ, Huang CY, Kuo CH, Kao CL, Shyu WC, Lee SD*. Anti-apoptotic and Pro-survival Effects of Food Restriction on High-Fat Diet-Induced Obese Hearts. Cardiovasc Toxicol. 2017 Apr;17(2):163-174. doi: 10.1007/s12012-016-9370-2. PMID: 27131981.
  141. (First Author) Lee SD, Kuo WW, Ho YJ, Lin AC, Day CH, Viswanadha VP, Wang HF, Kuo CH, Lai CH, Huang CY. Therapeutic effects of Dioscorea on post-menopause-induced cardiac apoptosis in rats. Chin J Integr Med. 2016 Jun 14. doi: 10.1007/s11655-016-2602-2. Epub ahead of print. PMID: 27299464. 141. 
  142. (Correspondence Author) Liou CM, Lee SP, Lee SD*. Cardiovascular Pathologic Changes Due to Methamphetamine Usage. Adaptive Medicine 8(2): 51-54, 2016 Jun. DOI10.4247/AM.2016.ABG142
  143. (Correspondence Author) Huang CY, Lin YY, Hsu CC, Cheng SM, Shyu WC, Ting H, Yang AL, Ho TJ, Lee SD*. Antiapoptotic effect of exercise training on ovariectomized rat hearts. J Appl Physiol (1985). 2016 Aug 1;121(2):457-65. doi: 10.1152/japplphysiol.01042.2015. Epub 2016 Jun 23. PMID: 27339185.
  144. Yang SC, Wang CC, Lee SD, Lee YU, Chan KH, Chen YL, Fogt DL, Kuo CH. Impact of 12-s Rule on Performance and Muscle Damage of Baseball Pitchers. Med Sci Sports Exerc. 2016 Dec;48(12):2512-2516. doi: 10.1249/MSS.0000000000001048. PMID: 27434082.
  145. Huang SC, Wu JF, Saovieng S, Chien WH, Hsu MF, Li XF, Lee SD, Huang CY, Huang CY, Kuo CH. Doxorubicin inhibits muscle inflammation after eccentric exercise. J Cachexia Sarcopenia Muscle. 2017 Apr;8(2):277-284. doi: 10.1002/jcsm.12148. Epub 2016 Oct 10. PMID: 27897404; PMCID: PMC5377412.
  146. (Correspondence Author) Lin YY, Cheng YJ, Hu J, Chu LX, Shyu WC, Kao CL, Lin TB, Kuo CH, Yang AL, Lee SD*. The Coexistence of Hypertension and Ovariectomy Additively Increases Cardiac Apoptosis. Int J Mol Sci. 2016 Dec 6;17(12):2036. doi: 10.3390/ijms17122036. PMID: 27929425; PMCID: PMC5187836. 146.    
  147. Masodsai K, Lin YY, Lee SD, Yang AL. Exercise and Endothelial Dysfunction in Hypertension. Adaptive Medicine, 2017, Mar 9(1): 1-14.
  148. Hsu MF, Yu SH, Korivi M, Jean WH, Lee SD, Huang CY, Liao YH, Lu J, Kuo CH. Hormetic Property of Ginseng Steroids on Anti-Oxidant Status against Exercise Challenge in Rat Skeletal Muscle. Antioxidants (Basel). 2017 May 19;6(2):36. doi: 10.3390/antiox6020036. PMID: 28534811; PMCID: PMC5488016.
  149. (Co-First Author#) Huang RJ#, Lai CH#, Lee SD#, Pai FY, Chang SW, Chung AH, Chang YF, Ting H. Objective Sleep Measures in Inpatients With Subacute Stroke Associated With Levels and Improvements in Activities of Daily Living. Arch Phys Med Rehabil. 2018 Apr;99(4):699-706. doi: 10.1016/j.apmr.2017.12.016. Epub 2018 Jan 12. Erratum in: Arch Phys Med Rehabil. 2018 Aug;99(8):1690. PMID: 29339206.
  150. (Correspondence Author) Huang C, Lin YY, Yang AL, Kuo TW, Kuo CH, Lee SD*. Anti-Renal Fibrotic Effect of Exercise Training in Hypertension. Int J Mol Sci. 2018 Feb 20;19(2):613. doi: 10.3390/ijms19020613. PMID: 29461477; PMCID: PMC5855835.
  151. (Correspondence Author) Chiu HC, Ada L, Lee SD*. Balance and mobility training at home using Wii Fit in children with cerebral palsy: a feasibility study. BMJ Open. 2018 May 15;8(5):e019624. doi: 10.1136/bmjopen-2017-019624. Erratum in: BMJ Open. 2018 Jul 16;8(7): PMID: 29764871; PMCID: PMC5961583.
  152. (Correspondence Author) Lin YY, Lee SD. Cardiovascular Benefits of Exercise Training in Postmenopausal Hypertension. Int J Mol Sci. 2018 Aug 25;19(9):2523. doi: 10.3390/ijms19092523. PMID: 30149647; PMCID: PMC6163560.
  153. (Co-First Author#) Huang RJ#, Lee SD#, Lai CH, Chang SW, Chung AH, Chen CW, Huang IN, Ting H. Objectively Measured Disrupted Sleep Is Independently and Directly Associated With Low Exercise Capacity in Males: A Structural Equation Model. J Clin Sleep Med. 2018 Dec 15;14(12):1995-2004. doi: 10.5664/jcsm.7522. PMID: 30518440; PMCID: PMC6287719.
  154. (Correspondence Author) Lin YY, Chen JS, Wu XB, Shyu WC, Chaunchaiyakul R, Zhao XL, Kuo CH, Cheng YJ, Yang AL, Lee SD*. Combined effects of 17β-estradiol and exercise training on cardiac apoptosis in ovariectomized rats. PLoS One. 2018 Dec 20;13(12):e0208633. doi: 10.1371/journal.pone.0208633. PMID: 30571718; PMCID: PMC6301615.
  155. (Co-Correspondence Author) Masodsai K, Lin YY, Chaunchaiyakul R, Su CT, Lee SD*, Yang AL*. Twelve-Week Protocatechuic Acid Administration Improves Insulin-Induced and Insulin-Like Growth Factor-1-Induced Vasorelaxation and Antioxidant Activities in Aging Spontaneously Hypertensive Rats. Nutrients. 2019 Mar 25;11(3):699. doi: 10.3390/nu11030699. PMID: 30934575; PMCID: PMC6471824.
  156. (Correspondence Author) Lin YY, Hong Y, Yu SH, Wu XB, Shyu WC, Chen JS, Ting H, Yang AL*, Lee SD*. Antiapoptotic and mitochondrial biogenetic effects of exercise training on ovariectomized hypertensive rat hearts. J Appl Physiol (1985). 2019 Jun 1;126(6):1661-1672. doi: 10.1152/japplphysiol.00038.2019. Epub 2019 Apr 18. PMID: 30998123.
  157. (Correspondence Author) Mao HY, Hsu HC, Lee SD*. Gender differences in related influential factors of regular exercise behavior among people in Taiwan in 2007: A cross-sectional study. PLoS One. 2020 Jan 31;15(1):e0228191. doi: 10.1371/journal.pone.0228191. PMID: 32004330; PMCID: PMC6993962.
  158. (Correspondence Author) Cheng SM, Ho YJ, Yu SH, Liu YF, Lin YY, Huang CY, Ou HC, Huang HL*, Lee SD*. Anti-Apoptotic Effects of Diosgenin in D-Galactose-Induced Aging Brain. Am J Chin Med. 2020;48(2):391-406. doi: 10.1142/S0192415X20500202. Epub 2020 Mar 5. PMID: 32138534.
  159. (Correspondence Author) Chen HI, Ou HC, Chen CY, Yu SH, Cheng SM, Wu XB*, Lee SD*. Neuroprotective Effect of Rhodiola crenulata in D-Galactose-Induced Aging Model. Am J Chin Med. 2020;48(2):373-390. doi: 10.1142/S0192415X20500196. Epub 2020 Mar 5. PMID: 32138536.
  160. (Correspondence Author) Lin YY, Hong Y, Zhou MC, Huang HL, Shyu WC, Chen JS, Ting H, Cheng YJ, Yang AL, Lee SD*. Exercise training attenuates cardiac inflammation and fibrosis in hypertensive ovariectomized rats. J Appl Physiol (1985). 2020 Apr 1;128(4):1033-1043. doi: 10.1152/japplphysiol.00844.2019. Epub 2020 Mar 12. PMID: 32163326.
  161. (Co-Correspondence Author) Lai CH, Huang RJ, Wong JK, Chang SW, Chung AH, Chi YC, Yu YC, Lee SD*, Ting H*. Confounded by obesity and modulated by urinary uric acid excretion, sleep- disordered breathing indirectly relates to hyperuricaemia in males: A structural equation model. J Sleep Res. 2020 Aug 6:e13108. doi: 10.1111/jsr.13108. Epub ahead of print. PMID: 32767532.
  162. (Correspondence Author) Cui JW, Hong Y, Kuo YM, Yu SH, Wu XB, Cui ZY*, Lee SD*. Voluntary exercise training attenuated the middle-aged maturity-induced cardiac apoptosis. Life Sci. 2020 Oct 15;259:118187. doi: 10.1016/j.lfs.2020.118187. Epub 2020 Aug 8. PMID: 32781061.
  163. (Co-Correspondence Author) Mahalakshmi B, Maurya N, Lee SD*, Bharath Kumar V*. Possible Neuroprotective Mechanisms of Physical Exercise in Neurodegeneration. Int J Mol Sci. 2020 Aug 16;21(16):5895. doi: 10.3390/ijms21165895. PMID: 32824367; PMCID: PMC7460620.
  164. (Co-Correspondence Author) Le TP, Tzeng YL, Muo CH, Ting H, Sung FC, Lee SD*, Teng YK*. Risk of hearing loss in patients with fibromyalgia: A nationwide population-based retrospective cohort study. PLoS One. 2020 Sep 3;15(9):e0238502. doi: 10.1371/journal.pone.0238502. PMID: 32881903; PMCID: PMC7470261.
  165. (Co-Correspondence Author) Cheng SM, Kumar VB, Wu LY, Chang HC, Kuo CH, Wei LS, Lin YM, Padma VV, Lee SD, Huang CY. Anti-apoptotic and pro-survival effects of longan flower extracts on rat hearts with fructose-induced metabolic syndrome. Environ Toxicol. 2021 Jan 21. doi: 10.1002/tox.23101. Epub ahead of print. PMID: 33475235.
  166. (Correspondence Author) Yun R, Bai Y, Lu Y, Wu X, Lee SD*. How Breathing Exercises Influence on Respiratory Muscles and Quality of Life among Patients with COPD? A Systematic Review and Meta-Analysis. Can Respir J. 2021 Jan 29;2021:1904231. doi: 10.1155/2021/1904231. PMID: 33574969; PMCID: PMC7864742.

 

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研究計畫

 

1 國家型,MOHW105-TDU-B-212-133019,許重義(Chung Y. Hsu),周德陽(Der-Yang Cho)、林欣榮(Shinn-Zong Lin)、姚俊旭(Chun-Hsu Yao)、蔡輔仁(Fuu-Jen Tsai)、邱俊誠(Jin-Chern Chiou)、林昭庚(Jaung-Geng Lin)、謝慶良(Ching-Liang Hsieh)、林正介(Cheng-Chieh Lin)、郭昭麟(Kuo Chao-Lin)、李信達(Shin-Da Lee)、徐偉成(Woei-Cherng Shyu)、張建國(Jan-Gowth Chang),衛生署,提升臨床試驗創新及競爭力計畫,$33781000,2016.1.1 ~ 2016.12.31
2 產學合作,103426AY,李信達(Shin-Da Lee),美律生醫股份有限公司,聽力復健創新模式,$600000,2016.1.1 ~ 2016.12.31
3 個別型,MOST 104-2314-B-039 -013 -MY3,李信達(Shin-Da Lee),國科會,運動治療與Stress-inducible protein 1對糖尿病腦部的影響,$860000,2015.8.1 ~ 2016.7.31
4 國家型,MOHW104-TDU-B-212-113002,許重義(Chung Y. Hsu),周德陽(Der-Yang Cho)、林欣榮(Shinn-Zong Lin)、吳金濱(Jin Bin Wu)、蔡輔仁(Fuu-Jen Tsai)、邱俊誠(Jin-Chern Chiou)、謝慶良(Ching-Liang Hsieh)、林正介(Cheng-Chieh Lin)、郭昭麟(Kuo Chao-Lin)、李信達(Shin-Da Lee)、徐偉成(Woei-Cherng Shyu),衛生署,提升臨床試驗創新及競爭力計畫,$31300000,2015.1.1 ~ 2015.12.31
5 產學合作,10342673,新視界教育股份有限公司,Frequency following Response(FFR)合併睡眠力和運動力對專注力和學習成效評估,$240000,2015.1.1 ~ 2015.12.31
6 產學合作,MOST 103-2622-B-039-002-CC3,李信達(Shin-Da Lee),國科會,步態復健機療效評估,$700000,2014.11.1 ~ 2015.10.31
7 個別型,MOST 103-2314-B-039-005,李信達(Shin-Da Lee),郭家驊,國科會,運動治療保護高血壓心臟新機轉:全基因、血管增生、幹細胞、抗老化、抗凋亡、抗纖維化,$815000,2014.8.1 ~ 2015.7.31
8 國家型,MOHW103-TDU-B-212-113002,許重義(Chung Y. Hsu),周德陽(Der-Yang Cho)、林欣榮(Shinn-Zong Lin)、吳金濱(Jin Bin Wu)、蔡輔仁(Fuu-Jen Tsai)、邱俊誠(Jin-Chern Chiou)、謝慶良(Ching-Liang Hsieh)、林正介(Cheng-Chieh Lin)、郭昭麟(Kuo Chao-Lin)、李信達(Shin-Da Lee)、徐偉成(Woei-Cherng Shyu),衛生署,103-105年提升臨床試驗創新及競爭力計畫,$33000000,2014.2.27 ~ 2014.12.31
9 個別型,NSC 100-2314-B-039-016-MY,李信達(Shin-Da Lee),郭家驊、黃志揚(Chih-Yang Huang)、徐偉成(Woei-Cherng Shyu),國科會,運動治療與Exchange protein activated by cAMP (Epac1)對糖尿病心臟與腦部的幹細胞自誘導機轉與抗凋亡機轉,$614000,2013.8.1 ~ 2014.7.31
10 個別型,102-2410-H-468-029-,鄭秀敏,李信達(Shin-Da Lee),,間歇性缺氧對於缺氧誘發因子調控心肌細胞凋亡與存活訊息途徑之機轉與治療探討: 1.紅景天?補充對長期間歇性缺氧誘發心肌細胞凋亡影響差異 2. 運動治療3. 紅景天?補充配合運動治療,$869000,2013.8.1 ~ 2014.7.31
11 個別型,102-2410-H-128-003-,陳淑滿,郭家驊(Chia-Hua Kuo)、李信達(Shin-Da Lee),,女性經期過程心情與運動技能之演變:硫酸?氫表雄酮所扮演的角色,$327000,2013.8.1 ~ 2014.7.31
12 整合型(召集人、總主持人),NSC 100-2632-B-039 -001 -MY3,許重義(Chung Y. Hsu),王玉田(Yu-Tian Wang)、林欣榮(Shinn-Zong Lin)、徐偉成(Woei-Cherng Shyu)、李信達(Shin-Da Lee),國科會,多重谷氨酸次型受體導致腦中風後神經元死亡之機制-多重谷氨酸次型受體導致腦中風後神經元死亡之機制(3/3),$3300000,2013.8.1 ~ 2014.7.31
13 國家型,DOH102-TD-B-111-004,許重義(Chung Y. Hsu),李源德(Yuan-Teh, Lee)、陳偉德(Walter Chen)、周德陽(Der-Yang Cho)、林欣榮(Shinn-Zong Lin)、蔡輔仁(Fuu-Jen Tsai)、邱俊誠(Jin-Chern Chiou)、謝慶良(Ching-Liang Hsieh)、吳天賞(Tian-Shung Wu)、吳永昌(Yang-Chang Wu)、林正介(Cheng-Chieh Lin)、郭昭麟(Kuo Chao-Lin)、李信達(Shin-Da Lee)、徐偉成(Woei-Cherng Shyu)、鄭光甫(Kuang-Fu Cheng),衛生署,中風及其他神經疾病專科卓越臨床試驗與研究中心計畫,$32974000,2013.1.1 ~ 2013.12.31
14 個別型,NSC 100-2314-B-039-016-MY,李信達(Shin-Da Lee),國科會,運動治療與Exchange protein activated by cAMP (Epac1)對糖尿病心臟與腦部的幹細胞自誘導機轉與抗凋亡機轉,$614000,2012.8.1 ~ 2013.7.31
15 個別型,NSC 99-2314-B-039-006-MY3,李信達(Shin-Da Lee),國科會,運動治療與MMP9在老年肥胖症誘發腎臟疾病扮演的角色:1.腎發炎與纖維化;2.運動治療療效;3.運動治療在MMP9 knock out 機轉,$785000,2012.8.1 ~ 2013.7.31
16 整合型項下子計畫(主持人),NSC 100-2632-B-039 -001 -MY3,許重義(Chung Y. Hsu),王玉田(Yu-Tian Wang)、林欣榮(Shinn-Zong Lin)、徐偉成(Woei-Cherng Shyu)、李信達(Shin-Da Lee),國科會,多重谷氨酸次型受體導致腦中風後神經元死亡之機制-多重谷氨酸次型受體導致腦中風後神經元死亡之機制(2/3),$3300000,2012.8.1 ~ 2013.7.31
17 個別型,CMU100-ASIA-08,李信達(Shin-Da Lee),,語言認知與運動調適研究平台,$1020000,2012.5.15 ~ 2013.5.14
18 國家型,DOH101-TD-B-111-004,許重義(Chung Y. Hsu),李源德(Yuan-Teh, Lee)、陳偉德(Walter Chen)、周德陽(Der-Yang Cho)、林欣榮(Shinn-Zong Lin)、蔡輔仁(Fuu-Jen Tsai)、邱俊誠(Jin-Chern Chiou)、謝慶良(Ching-Liang Hsieh)、吳天賞(Tian-Shung Wu)、吳永昌(Yang-Chang Wu)、林正介(Cheng-Chieh Lin)、郭昭麟(Kuo Chao-Lin)、李信達(Shin-Da Lee)、徐偉成(Woei-Cherng Shyu)、鄭光甫(Kuang-Fu Cheng),衛生署,中風及其他神經疾病專科卓越臨床試驗與研究中心計畫,$35445000,2012.1.1 ~ 2012.12.31
19 個別型,NSC 98-2320-B-039-020-MY3,歐秀中(Hsiu-Chung Ou),李信達(Shin-Da Lee),國科會,芝麻素在體外及體內之抗動脈硬化作用,$1015000,2011.8.1 ~ 2012.7.31
20 整合型(召集人、總主持人),NSC 100-2632-B-039-001-MY,許重義(Chung Y. Hsu),王玉田(Yu-Tian Wang)、林欣榮(Shinn-Zong Lin)、徐偉成(Woei-Cherng Shyu)、李信達(Shin-Da Lee),國科會,多重谷氨酸次型受體導致腦中風後神經元死亡之機制-多重谷氨酸次型受體導致腦中風後神經元死亡之機制,$3300000,2011.8.1 ~ 2012.7.31
21 個別型,NSC 100-2314-B-039-016-MY,李信達(Shin-Da Lee),國科會,運動治療與Exchange protein activated by cAMP (Epac1)對糖尿病心臟與腦部的幹細胞自誘導機轉與抗凋亡機轉,$614000,2011.8.1 ~ 2012.7.31
22 個別型,NSC 99-2314-B-039-006-MY3,李信達(Shin-Da Lee),國科會,運動治療與MMP9在老年肥胖症誘發腎臟疾病扮演的角色:1.腎發炎與纖維化;2.運動治療療效;3.運動治療在MMP9 knock out 機轉,$785000,2011.8.1 ~ 2012.7.31
23 個別型,CMU99-COL-21-2,李信達(Shin-Da Lee),本校(含附醫),運動治療對肥胖心臟發炎途徑(toll-like receptor 4 and TNF-α pathway)的改善,$290000,2011.8.1 ~ 2012.4.30
24 產學合作,10042607,李信達(Shin-Da Lee),財團法人金屬工業研究發展中心,學界關懷-光昱活力健美機科技關懷診斷計畫,$72000,2011.7.1 ~ 2011.12.31
25 產學合作,NSC 100-2622-B-039-001-CC,李信達(Shin-Da Lee),國科會,智慧型失眠治療床開發與療效,$650000,2011.6.1 ~ 2012.5.31
26 非研究型計畫 (例如:課程計畫),10073055,李信達(Shin-Da Lee),,第24屆全國復健盃-物治系,$14000,2011.6.14 ~ 2011.12.31
27 個別型,CMU99-COL-21-1,李信達(Shin-Da Lee),本校(含附醫),運動治療對肥胖心臟發炎途徑(toll-like receptor 4 and TNF-α pathway)的改善,$60000,2011.5.1 ~ 2011.7.31
28 整合型項下子計畫(主持人),CMU99-ASIA-05,鄭宇容(Cheng, Yu-Jung),李信達(Shin-Da Lee),本校(含附醫),身心與認知調適研究平台-分項平台3,$400000,2011.4.1 ~ 2012.3.31
29 個別型,CMU99-ASIA-03,李信達(Shin-Da Lee),本校(含附醫),身心與認知調適研究平台-分項平台1,$2400000,2011.4.1 ~ 2012.3.31
30 個別型,NSC 100-2911-I-039-501,李信達(Shin-Da Lee),國科會,在台灣設立亞洲物理治療聯盟辦公室並承辦2013亞洲物理治療聯盟國際會議,$600000,2011.2.1 ~ 2012.1.31
31 國家型,DOH100-TD-B-111-004,許重義(Chung Y. Hsu),李源德(Yuan-Teh, Lee)、陳偉德(Walter Chen)、周德陽(Der-Yang Cho)、林欣榮(Shinn-Zong Lin)、蔡輔仁(Fuu-Jen Tsai)、邱俊誠(Jin-Chern Chiou)、謝慶良(Ching-Liang Hsieh)、吳天賞(Tian-Shung Wu)、吳永昌、林正介(Cheng-Chieh Lin)、郭昭麟(Kuo Chao-Lin)、李信達(Shin-Da Lee)、徐偉成(Woei-Cherng Shyu)、鄭光甫(Kuang-Fu Cheng),衛生署,中風及其他神經疾病專科卓越臨床試驗與研究中心計畫,$40500000,2011.1.1 ~ 2011.12.31
32 校內其他單位控管計畫(例如:教卓計畫),M3-1-CMU,李信達(Shin-Da Lee),本校(含附醫),國際化學習,$1635974,2011.1.1 ~ 2011.12.31
33 校內其他單位控管計畫(例如:教卓計畫),M3-1,李信達(Shin-Da Lee),,國際化學習,$8872137,2011.1.1 ~ 2011.12.31
34 非研究型計畫 (例如:課程計畫),10073171,李信達(Shin-Da Lee),,經濟部推動國際會議及展覽在台辦理計劃,$270000,2011.1.1 ~ 2011.12.31
35 產學合作,0994266K,李信達(Shin-Da Lee),上銀科技股份有限公司,步態復健機研究開發,$230000,2010.11.1 ~ 2011.4.30
36 個別型,NSC 98-2320-B-039-020-MY3,歐秀中(Hsiu-Chung Ou),李信達(Shin-Da Lee),國科會,芝麻素在體外及體內之抗動脈硬化作用,$950000,2010.8.1 ~ 2011.7.31
37 個別型,NSC 99-2314-B-039-006-MY3,李信達(Shin-Da Lee),國科會,運動治療與MMP9在老年肥胖症誘發腎臟疾病扮演的角色:1.腎發炎與纖維化;2.運動治療療效;3.運動治療在MMP9 knock out 機轉,$665000,2010.8.1 ~ 2011.7.31
38 個別型,NSC 97-2314-B-039-002-MY3,李信達(Shin-Da Lee),國科會,停經對於心臟FAS, MITOCHONDRIAL, CASPASE-INDEPENDENT 凋亡的影響和治療的探討:1. 山藥補充 2. DIASGENIN補充 3.DIASGENIN補充配合運動療效,$1780000,2010.8.1 ~ 2011.10.31
39 個別型,CMU99-S-11,李信達(Shin-Da Lee),本校(含附醫),運動治療在高血壓對於心臟細胞抗凋亡和PI3K-Akt存活途徑之療效探討,$340000,2010.8.1 ~ 2011.7.31
40 個別型,99-2410-H-468-030-MY3,鄭秀敏,郭家驊(Chia-Hua Kuo)、李信達(Shin-Da Lee),,合併鎂補充劑和運動治療在糖尿病對於神經細胞抗凋亡途徑和神經營養因子調控之療效探討,$992000,2010.8.1 ~ 2013.7.31
41 產學合作,0994268F,李信達(Shin-Da Lee),財團法人自行車暨健康科技工業研究發展中心,上肢復健之訓練流程與課程內容研究規劃,$150000,2010.4.1 ~ 2010.12.31
42 整合型(召集人、總主持人),CMU98-ASIA-07、08,李信達(Shin-Da Lee),李淑貞、李舒萍、鄭秀敏、歐秀中(Hsiu-Chung Ou),本校(含附醫),長照與身心健康促進轉譯研究平臺(分項平台1及2),$2000000,2010.2.1 ~ 2011.1.31
43 整合型項下子計畫(主持人),NSC 100-2321-B-039 -001,陳偉德(Walter Chen),陳階曉(CHIEH-HSIAO CHEN)、林必盛(Bih-Chern Lin)、蔡銘修(Ming-Hsui Tsai)、吳介信(Chieh-Hsi Wu)、徐偉成(Woei-Cherng Shyu)、李信達(Shin-Da Lee)、周立偉(Li-Wei Chou)、蔡昆熹(Kun-Hsi Tsai)、韓鴻志(Horng-Jyh Harn)、沈淵瑤(Ein-Yiao Shen),國科會,醫療器材跨領域萌芽創新計畫,$5000000,2010.2.1 ~ 2011.1.31
44 整合型項下子計畫(主持人),CMU98-CT-23,李信達(Shin-Da Lee),鄭宇容(Cheng, Yu-Jung),本校(含附醫),ENHANCEMENT OF STEM CELLS RECRUITMENT AFTER ISCHEMIC STROKE IN EXERCISE CONDITIONED MICE,$500000,2009.12.1 ~ 2010.11.30
45 個別型,CMU98-CT-23,李信達(Shin-Da Lee),本校(含附醫),ENHANCEMENT OF STEM CELLS RECRUITMENT AFTER ISCHEMIC STROKE IN EXERCISE CONDITIONED MICE,$500000,2009.12.1 ~ 2010.11.30
46 產學合作,NSC 98-2622-B-039-004-CC3,李信達(Shin-Da Lee),國科會,抗心臟傷害植物性新藥開發,$683000,2009.11.1 ~ 2010.10.31
47 校內其他單位控管計畫(例如:教卓計畫),NSC 98-2314-B-039-002,李信達(Shin-Da Lee),國科會,SIRT1 ACTIVATORS配合運動治療對第二型糖尿病抗老化延壽和抗心臟細胞凋亡的療效探討(擴增計劃專任助理-簡美華),$465101,2009.9.1 ~ 2010.7.31
48 個別型,NSC 98-2314-B-039-002,李信達(Shin-Da Lee),國科會,SIRT1 ACTIVATORS配合運動治療對第二型糖尿病抗老化延壽和抗心臟細胞凋亡的療效探討,$800000,2009.8.1 ~ 2010.7.31
49 個別型,CMU98-S-14,李信達(Shin-Da Lee),本校(含附醫),ALPHA-GLUCOSIDASE INHIBITOR配合運動治療在第二型糖尿病對於心臟細胞抗凋亡和INSULIN-PI3K-AKT存活途徑之療效探討,$350000,2009.8.1 ~ 2010.7.31
50 個別型,NSC 98-2320-B-039-020-MY3,歐秀中(Hsiu-Chung Ou),李信達(Shin-Da Lee),國科會,芝麻素在體外及體內之抗動脈硬化作用,$900000,2009.8.1 ~ 2010.7.31
51 個別型,NSC 97-2314-B-039-002-MY3,李信達(Shin-Da Lee),國科會,停經對於心臟FAS, MITOCHONDRIAL, CASPASE-INDEPENDENT 凋亡的影響和治療的探討:1. 山藥補充 2. DIASGENIN補充 3.DIASGENIN補充配合運動療效,$1780000,2009.8.1 ~ 2010.7.31
52 校內其他單位控管計畫(例如:教卓計畫),98-教-方案7-B-63,李信達(Shin-Da Lee),教育部,SIRT1 ACTIVATORS配合運動治療對第二型糖尿病抗老化延壽和抗心臟細胞凋亡的療效探討,$408712,2009.8.1 ~ 2010.11.30
53 個別型,NSC95-2314-B-039-043-MY3,李信達(Shin-Da Lee),國科會,睪固酮對於心臟細胞凋亡的探討,$1081000,2008.8.1 ~ 2009.7.31
54 個別型,CMU97-071,白培英(Pei-Ying Pai),李信達(Shin-Da Lee),本校(含附醫),與台大合作計畫-ASSESSMENT OF CARDIAC HUPERTROPHY AND APOPTOSIS IN GENETIC OBESE ZUCKER RAT WITH NOCTURNAL INTERMITTENT HYPOXIA.,$500000,2008.8.1 ~ 2009.7.31
55 個別型,NSC 97-2314-B-039-002-MY3,李信達(Shin-Da Lee),國科會,停經對於心臟FAS, MITOCHONDRIAL, CASPASE-INDEPENDENT 凋亡的影響和治療的探討:1. 山藥補充 2. DIASGENIN補充 3.DIASGENIN補充配合運動療效,$1780000,2008.8.1 ~ 2009.7.31
56 個別型,CMU97-219,李信達(Shin-Da Lee),本校(含附醫),運動治療在糖尿病對心臟細胞抗凋亡和PI3K-AKT存活涂儘之療效探討,$500000,2008.8.1 ~ 2009.6.30
57 個別型,CMU96-209,李信達(Shin-Da Lee),本校(含附醫),睪固酮對於心臟細胞凋亡的探討(2/3),$212100,2007.8.1 ~ 2008.7.31
58 個別型,CMU96-101,李信達(Shin-Da Lee),本校(含附醫),糖尿病誘發心臟細胞凋亡機轉與胰島素抗凋亡療效之探討,$500000,2007.8.1 ~ 2008.6.30
59 個別型,NSC95-2314-B-039-043-MY3,李信達(Shin-Da Lee),國科會,睪固酮對於心臟細胞凋亡的探討,$1115000,2007.8.1 ~ 2008.7.31
60 個別型,CMU95-262,李信達(Shin-Da Lee),本校(含附醫),睪固酮對於心臟細胞凋亡的探討,$500000,2006.12.11 ~ 2007.7.31
61 個別型,NSC 95-2314-B-039-040,李信達(Shin-Da Lee),黃志揚,國科會,肥胖症心臟凋亡途徑與治療的探討,$550000,2006.8.1 ~ 2007.7.31
62 個別型,CMU95-278,李信達(Shin-Da Lee),本校(含附醫),研發處一億元研究專案-在肥胖症中dopamine作用在腦中央D2接受體對 缺氧的換氣反應,$201000,2006.8.1 ~ 2007.7.31
63 個別型,CMU95-235,李信達(Shin-Da Lee),本校(含附醫),研發處一億元研究專案-在肥胖症中內因性opioids作用在 mu1, mu2,接受體對 缺氧的換氣反應,$1799000,2006.8.1 ~ 2007.7.31
64 個別型,NSC 95-2314-B-006-073-MY2,(楊艾倫(成大)),李信達(Shin-Da Lee),國科會,停經對於心臟凋亡及血管功能的影響和荷爾蒙與運動治療的探討,$1881000,2006.8.1 ~ 2008.7.31
65 個別型,CMU95-215,李信達(Shin-Da Lee),本校(含附醫),山藥對卵巢切除鼠心肌細胞肥大與心肌細胞凋亡的探討,$500000,2006.8.1 ~ 2007.7.31
66 個別型,NSC95-2314-B-039-043-MY3,李信達(Shin-Da Lee),國科會,睪固酮對於心臟細胞凋亡的探討,$1001000,2006.8.1 ~ 2007.7.31
67 個別型,NSC95-2314-B-039-040-,李信達(Shin-Da Lee),黃志揚,國科會,肥胖症心臟凋亡途徑與治療的探討:肥胖症心臟 TYPE I 和 TYPE II 的凋亡;ACE INHIBITOR治療對肥胖心臟凋亡的保護;運動治療對肥胖心臟凋亡的改善 (2/2),$550000,2006.8.1 ~ 2007.7.31
68 個別型,NSC 94-2314-B-040-007,李信達(Shin-Da Lee),黃志揚,國科會,肥胖症心臟凋亡途徑與治療的探討: 肥胖症心臟Type I 和Type II 的凋亡; ACE inhibitor治療對肥胖心臟凋亡的保護 ;運動治療對肥胖心臟凋亡的改善 (1/2),$571000,2005.8.1 ~ 2006.7.31
69 個別型,NSC 94-2314-B-040-008,李信達(Shin-Da Lee),黃志揚,國科會,間歇性缺氧對心肌擴張及心肌凋亡之探討,$822000,2005.8.1 ~ 2006.7.31
70 個別型,NSC 93-2314-B-040-002,李信達(Shin-Da Lee),國科會,在肥胖症中內因性opioids作用在 mu, delta, or kappa 接受體對心肺功能和運動的調節(2/2),$525700,2004.8.1 ~ 2005.7.31
71 個別型,NSC 93-2314-B-040-011,李信達(Shin-Da Lee),國科會,在肥胖症中低氧誘發心肌凋亡和心肌病變,$470000,2004.8.1 ~ 2005.7.31
72 個別型,NSC 92-2314-B-040-015,李信達(Shin-Da Lee),國科會,在肥胖症中內因性opioids作用在 mu, delta, or kappa 接受體對心肺功能和運動的調節(1/2),$518400,2003.8.1 ~ 2004.7.31
73 個別型,NSC 91-2314-B-040-025,李信達(Shin-Da Lee),國科會,在肥胖症中dopamine 作用在 D1, D 2, D3, or D4 接受體對換氣和運動的調節,$748000,2002.8.1 ~ 2003.7.31
74 個別型,NSC 90-2314-B-040-022 (大專生參與計畫),李信達(Shin-Da Lee),國科會,在肥胖症中adenosine對呼吸和運動最大耗氧量的調節,$75000,2001.1.1 ~ 2002.7.31